RESUMO
Infection of Human T-lymphotropic virus type-I (HTLV-I) was investigated by long-term follow up surveys of mother's milk-fed infants. HTLV-I infections of infants via seropositive mother's milk, that is, anti-HTLV-I antibody-positive infants, increased in number up to the age 2, but no infants became antibody-positive thereafter. Infants who had became antibody positive by age 2 remained so at age 11-12. HTLV-I infection via feeding with mother's milk was established by the age 2. While in epidemiologic surveys an increase of the anti-HTLV-I antibody-positive rate has been reported, this survey revealed that after acquisition of HTLV-I from breast feeding, there was no further horizontal transmission prior to puberty.
Assuntos
Aleitamento Materno , Anticorpos Antideltaretrovirus/sangue , Infecções por HTLV-I/transmissão , Transmissão Vertical de Doenças Infecciosas , Feminino , Soropositividade para HIV/sangue , Infecções por HTLV-I/imunologia , Humanos , Recém-Nascido , Estudos LongitudinaisRESUMO
Human T-lymphotropic virus Type-I (HTLV-I) infects children via mother's milk. Infection of Human T-lymphotropic virus Type-I (HTLV-I) was investigated by long-term follow-up surveys of modified milk-fed children. Our observations of modified milk-fed infants revealed that: 1 of 154 (0.6%) at year 1, 5 of 129 (3.9%) at 1.5 years, and 5 of 108 (4.6%) at year 2 were anti-HTLV-I antibody-positive. No infants or children became newly antibody-positive thereafter. Modified milk feeding could prevent the HTLV-I infection of infants from mothers in many cases, however the infants who had became anti-HTLV-I antibody-positive due to established infection by the age 2 remained positive at age 11-12 with persistent infections. Modified milk-fed infants who had been born from HTLV-I seropositive mothers did not show that they had complete protection from HTLV-I infection, but a low infection rate was seen, showing that modified milk feeding is useful to protect from HTLV-I infection.
Assuntos
Alimentação com Mamadeira , Anticorpos Anti-HTLV-I/sangue , Infecções por HTLV-I/imunologia , Infecções por HTLV-I/transmissão , Transmissão Vertical de Doenças Infecciosas , Leite , Animais , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Masculino , Leite Humano/virologia , GravidezAssuntos
Mola Hidatiforme Invasiva/terapia , Neoplasias Uterinas/terapia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Terapia Combinada , Dactinomicina/administração & dosagem , Feminino , Humanos , Mola Hidatiforme Invasiva/patologia , Mola Hidatiforme Invasiva/secundário , Leucovorina/administração & dosagem , Neoplasias Pulmonares/secundário , Metotrexato/administração & dosagem , Pessoa de Meia-Idade , Gravidez , Neoplasias Uterinas/patologia , Vincristina/administração & dosagemRESUMO
When pregnant women were tested for antibody to human T-cell leukemia virus-I, some were found to be positive although they had been negative during the previous pregnancy. In these women, HTLV-I infection was found from pedigree studies to have been acquired from their mothers rather than from their husbands. Furthermore, some of them had apparently remained HTLV-I antibody-negative for long periods after infection. When the breast-fed children of these women, in whom HTLV-I was acquired from their mothers but who were in an HTLV-I antibody-negative state, were also examined for evidence of HTLV-I infection, none was found.
